منابع مشابه
From systems biology to synthetic biology
If each of us conveys our idiosyncratic view of the elephant, then we, in communion, can imagine its wholeness (Ireland, 1997). An analogous process elucidates Molecular Systems Biology (MSB) and this journal is dedicated to it. The work of a scientist/engineer (seer for short) consists of discovery, modeling, perturbation, and invention. Cycling through these is a key practice of biology. Addi...
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This paper describes how to classify a family of biochemical pathways and circuits in terms of their temporal behavior by systematic application of time-frequency analysis and temporal logic based model checking. There are two immediate pay-offs for this approach. First, a family of models obtained by systematic perturbations of an archetypal (e.g., wild-type or ancestral) model, when classifie...
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On June 26, 2000, President Bill Clinton and Prime Minister Tony Blair, along with Francis Collins, director of the Human Genome Project at the NIH, and Craig Venter, president of Celera Genomics, announced the arrival of the genomic era with the sequencing of the first draft sequence of the human genome. With this wealth of information, scientists and policy-makers alike were eager to welcome ...
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Plant metabolism represents an enormous repository of compounds that are of pharmaceutical and biotechnological importance. Engineering plant metabolism into microbes will provide sustainable solutions to produce pharmaceutical and fuel molecules that could one day replace substantial portions of the current fossil-fuel based economy. Metabolic engineering entails targeted manipulation of biosy...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2005
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb4100007